12/16/2023 0 Comments Universal antidoteThe scientists saw a 4% to 60% reduction in infections compared with when they exposed the cells to the virus without activated carbon present. Dilutions of plain activated carbon were able to reduce the infection of cells in the lab when applied to the cells prior to exposure to HSV-1 or HSV-2. The research team looked at the effect of both plain activated carbon and activated carbon plus acyclovir on HSV-1 and HSV-2. Also, using murine models of corneal and genital herpes infections, we show that the topical use of drug-encapsulated carbon (DECON) reduced dosing frequency, shortened treatment duration, and exhibited higher therapeutic efficacy than currently approved topical or systemic antivirals alone.” “Our in vitro studies demonstrate that highly porous carbon structures trapped virions blocked infection and substantially improved efficacy when ACV was loaded onto them. “In our quest to inhibit herpes simplex virus infection via the compounds found in commonly used cosmetic products, we found that activated carbon particles inhibit infection and, in addition, substantially improve topical delivery and, hence, the efficacy of a common antiviral drug, acyclovir (ACV),” the authors wrote. Particles tend to bind to charcoal easily and it is often used in filters for water for this reason. Activated carbon is known to have purifying effects by trapping toxins in its highly porous structure. However, long-term use often results in resistance to the drug as well as kidney damage. Moreover, treatment for both infections often includes acyclovir-a systemic medication taken orally. There are two types of herpes simplex virus: herpes simplex 1, which infects the eyes and mouth and is a leading cause of blindness, and herpes simplex 2, a genital infection that causes warts and can seriously impair quality of life. “Using less of the drug can help reduce the risk of kidney damage, which can be significant when these drugs are used over long periods of time.” “Combing herpes medication with activated charcoal makes the drug much more efficient so less of the drug is needed to achieve the same effect,” explained senior study investigator Deepak Shukla, PhD, professor of ophthalmology, microbiology, and immunology in the UIC College of Medicine.
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